The 6th seminar of the UniGR-Center for Border Studies organised by the University of Liège was held online on 8 and 9 June 2020. This new format was chosen in response to the health crisis and the constraints imposed on participants in the different parts of the Greater Region. This edition of the seminar was devoted to the long-term challenges linked to cross-border mobility in the Greater Region, with a particular focus on the relationship between this mobility and the organization of work in this territory.