The aim of the project Improve-Stem is to develop an integrated set of tools required for mesenchymal stem cell amplification (MSC) to promote their application in clinical cell therapy. Those tools will be based on the development of microcarriers with optimised surface design allowing the control of cell adhesion alongside to the design of an adapted bioreactor with operating conditions adjusted for stem cell culture on microcarriers. Cell behavior will be monitored to ensure quality, homogeneity and purety of the cells.